Hyperthermia and Thermosensitive Liposomes for Improved Delivery of Chemotherapeutic Drugs to Solid Tumors

Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors.

Hyperthermia Induced Gadodiamide Release from Thermosensitive Liposomes in Solid Tumors and Muscle Tissue

Introduction: Thermal dose is the key factor for the synergistic interaction of local hyperthermia (HT) in combination with chemotherapy in tumor therapy (1,2); for targeting and accumulation of liposomes in a target volume, for triggering fast and efficient content release from thermosensitive liposomes (TSL) in that target volume. Thus, for experimental investigation of TSL and for a potentia...

Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation resul...

Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy.

Liposome mediated anticancer drug delivery has the advantage of reducing cytotoxicity in healthy tissues. However, undesired slow drug release impedes the therapeutic efficacy of clinically applied PEG-liposomal doxorubicin (Dox). The aim of this study is to combine stealth thermosensitive liposomes (TSL) and local mild hyperthermia (HT) to increase bioavailable Dox levels in tumors. Dox was en...

MRI-monitoring of hyperthermia induced Gadodiamide release from long-circulating thermosensitive liposomes in tumors

M. Peller, A. Schwerdt, M. Hossann, H. M. Reinl, R. D. Issels, L. Lindner, and M. Reiser Department of Clinical Radiology, University Hospital of Munich, Munich, Germany, Pharmaceutical Biology-Biotechnology, Department for Pharmacy, University of Munich, Germany, Department of Medicine III, University Hospital of Munich, Germany, Institute for Molecular Immunology, KKG "Hyperthermia"/GSF-Natl....